This book presents the proceedings of the 26th Medical Informatics in Europe Conference (MIE2015), held in Madrid, Spain, in May 2015.

The conference brings together participants who share their latest achievements in biomedical and health Informatics, including the role of the user in digital healthcare, and provides a forum for discussion of the inherent challenges to design and adequately deploy ICT tools, the assessment of health IT interventions, the training of users and the exploitation of available information and knowledge to further the continuous and ubiquitous availability and interoperability of medical information systems. Contributions address methodologies and applications, success stories and lessons learned as well as an overview of on-going projects and directions for the future.